Clinical Research

A resource to get the latest clinical evidence, studies, models and frameworks to advance knowledge of how best to manage chronic health conditions.

Welldoc is committed to our scientific research, advancing digital health, transforming chronic care, and driving value across healthcare. Areas of focus include digital health engagement, advancing artificial intelligence, cardiometabolic condition outcomes, cost and value, and real-world integration into the health ecosystem.

Behavioral Factors, Empowerment Bolsters Self-Management

The increasing use of web-based or technology-enabled solutions for health management presents opportunities to improve patient self-management…
A Novel Approach to Continuous Glucose Monitoring
Health Plan Opportunities to Control Costs Related to Chronic Disease
Moving the Dial in Lowering and Controlling A1C
The Power of Integrated Peer Support and Digital Health
A Novel Approach to Continuous Glucose Monitoring
Health Plan Opportunities to Control Costs Related to Chronic Disease
Health Plan Opportunities to Control Costs Related to Chronic Disease
Moving the Dial in Lowering and Controlling A1C
The Power of Integrated Peer Support and Digital Health
The Power of Integrated Peer Support and Digital Health
Topics
Clinical Bibliography Theme
Type
Clinical Bibliography Type
Healthcare Analytics
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Poster
Evaluating a State-of-the-art Generative Pre-trained Transformer Model to Predict Continuous Glucose Monitoring Values at Different Time Intervals
Welldoc is actively developing generative-AI models specific to continuous glucose monitoring (CGM) value prediction. Our GPT-like AI modeling approach, based on a vast CGM dataset for individuals with type 1 and type 2 diabetes, has achieved state-of-the-art performance in predicting short-term CGM trajectories, at five-minute intervals, up to two hours in advance. Specifically, when predicting one of the 5 glucose categories (VeryLow, Low, InRange, High, VeryHigh), the model demonstrated an overall accuracy of 94% in predicting CGM values within 30 minutes. The absolute prediction accuracy to predict glucose values within 5mg/dL and 10 mg/dL error range in 30mins was 62% and 80% respectively. This exceptional accuracy highlights the model's potential to provide valuable insights into the dynamic interplay between blood sugar levels, lifestyle factors, and interventions. By leveraging these insights, personalized, automated coaching can be developed to optimize diabetes management and improve individual outcomes. This work is integral to Welldoc’s Advanced AI and our ability to transform the care continuum.

Mansur Shomali, MD, CM, Junjie Luo, MS, Abhimanyu Kumbara, MS, Anand Iyer, PhD, Gordon Gao, PhD

Healthcare Analytics
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Poster
CGM-GPT: A Transformer Based Glucose Prediction Model to Predict Glucose Trajectories at Different Time Horizons
Welldoc is pioneering the use of AI to revolutionize diabetes management. Our groundbreaking general purpose transformer based CGM research represents a significant leap forward in predicting glucose levels for individuals living with both Type 1 and Type 2 diabetes.

This research is the first in a series outlining Welldoc's novel methodology towards predicting future continuous glucose monitoring (CGM) glucose levels with high accuracy. The poster presents Welldoc's state-of-the-art AI models, which can predict glucose trajectories at 30-, 60- and 120-minute intervals for both type 1 and type 2 diabetes populations with ~ 50% less root mean square error, when compared to existing benchmark studies. Welldoc's GPT model, CGM-GPT, was trained only on CGM data sets from individuals living with Type 1 and Type 2 diabetes, and reflects the advanced opportunity to develop sophisticated large sensor models (LSM) by leveraging the vast data available via real-time sensors.

We are committed to further refining our models by incorporating additional data sources and exploring expanded applications. This ongoing research will drive the development of innovative diabetes management solutions. Stay tuned for additional information on our exciting transformer based CGM research.

Junjie Luo, MS, Abhimanyu Kumbara, MS, Mansur Shomali, MD, CM, Anand Iyer, PhD, Gordon Gao, PhD

Healthcare Models and FrameworksIntegration into Care
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Poster
A Dynamic Duo: Virtual DSMES and a Digital App, a New Model for Self-Management Education
Cardiometabolic digital health solutions, which address conditions like diabetes, are increasingly becoming integrated into clinical care models. Inclusion of AI-driven, personalized coaching can empower individuals towards better self-management and healthy habits, while also providing data-driven, actionable insights to drive optimized clinical decisions, increased clinical efficiency, and scalability of cardiometabolic health programs.

Allina Health, a nonprofit health system that cares for individuals, families and communities throughout Minnesota and western Wisconsin, collaborated with Welldoc to launch an integrated Diabetes Self-Management Education and Support (DSMES) program. This poster delves into the real-world learnings across this multi-year initiative. Allina's Certified Diabetes Care and Education Specialists (CDCES) share critical factors in standing up an integrated digital-first program and valuable insights demonstrating how digitally enabled programs can drive improved reach, access, health outcomes and operational efficiency. Learn how Allina Health overcame challenges, demonstrated patient engagement, and enhanced operational efficiency throughout this impactful initiative.

Dawn McCarter, RN, BSN, CDCES Program Manager Allina Health Diabetes Education; Jennifer Scarsi RD, CDCES Clinical Digital Solutions Specialist

Healthcare AnalyticsPatient Experience
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Poster
Use of a Digital Health Tool to Amplify Patient Engagement with the ADCES7 Self-Care Behaviors®
Welldoc continues to research how AI-driven personalized digital health solutions can motivate and support better engagement, self-management and overall health. This Welldoc study analyzed digital health engagement patterns among individuals with type 1 and type 2 diabetes. Individuals who utilized the app to set goals and participate in simple health challenges, focused on building better habits, engaged with the app up to 8x more than those who did not. This indicates how breaking down health goals into manageable and how personalized steps can significantly increase digital health engagement and foster heathier routines.

Catherine Brown, Anand Iyer, Abhi Kumbara, Mansur Shomali, Malinda Peeples

Healthcare AnalyticsPatient Experience
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Poster
Use of a Digital Health Tool to Support People with Diabetes Who Inject Bolus Insulin Improves the Glycemia Risk Index and Time in Tight Range
Continuous glucose monitoring (CGM) has emerged as an important tool to help people with diabetes manage food, activity, and insulin dosing. CGM measures Time in Range (TIR) and has become a key metric for clinical practice.

Building upon Welldoc’s research on the impact of CGM + digital health, this analysis sought to correlate the glycemic metrics, time in tight range (TITR) and glycemic risk index (GRI), to level of engagement with the digital health tool. Highlights from the study include further understanding of TIR improvement, particularly for those with type 2 diabetes, and initial findings specific to engagement with a digital health insulin calculator feature. Welldoc continues research in this area to drive further integration of GIR and TITR into AI-driven digital health solutions, to impact user engagement and cardiometabolic health.

Mansur Shomali, MD, Maxwell Ebert, MPH, Anand Iyer, PhD, Jean Park, MD, and Grazia Aleppo, MD

Healthcare AnalyticsHealthcare Models and Frameworks
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Presentation
Using an Automated, Real-time Data Enabled Feature Engineering Process to Predict Future Weight Outcomes
This research presents a novel artificial intelligence (AI) framework for building dynamic user profiles, based on interactions with digital health app features. This framework makes it possible to identify individual-level use-patterns and develop advanced AI models to accurately predict and effectively influence health outcomes.

In this research, Welldoc analyzed continuous glucose monitoring (CGM) + My E-Diary for Activities and Lifestyle (MEDAL) data, as collected within Welldoc’s cardiometabolic digital health platform to determine features and use patterns which influence future weight loss. This study proposes a novel AI framework to build dynamic user profiles based on how users interact with digital health apps. The researchers analyzed continuous glucose monitoring (CGM) and MEDAL data collected within Welldoc's digital health platform, to find patterns that could predict future weight loss. Continued research in this area will ultimately drive the development of next generation, personalized digital health solutions that further impact the user experience, individual behaviors and overall health outcomes.

Junjie Luo, Abhimanyu Kumbara, MS, MBA, Anand K. lyer, PhD, MBA, Mansur E. Shomali, MD, CM, Guodong (Gordon) Gao, PhD

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Taking Diabetes Self-Management to the Next Level